Autoimmune Disease
Researchers at Oregon Health & Science University have pinpointed specific sites on NMDA receptors targeted by harmful antibodies in a rare autoimmune brain disorder known as "Brain on Fire." This discovery, published in Science Advances, could lead to more precise treatments and earlier detection. The condition affects about 1 in 1 million people annually, mainly young adults, causing severe symptoms like seizures and memory loss.
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Researchers have uncovered the strongest evidence yet that the Epstein-Barr virus, which causes glandular fever, triggers lupus by reprogramming immune cells. The study reveals how the virus infects B-cells, leading to a hyperactive immune response that attacks healthy tissues. This finding could explain the success of certain therapies and support vaccine development.