Microglia
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University of Kentucky study links microglia to sleep loss in Alzheimer’s-model mice
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Researchers at the University of Kentucky report that overactive microglia—immune cells in the brain—can drive sleep loss in mice with amyloid plaques. In the study, temporarily depleting most microglia restored more than two hours of sleep per day, even though plaque levels did not change.
Researchers at the University of Utah have found that anxiety in mice is regulated by two groups of microglia, immune cells that act as accelerators and brakes. This discovery challenges the traditional focus on neurons for mental health issues. The findings, published in Molecular Psychiatry, suggest potential new approaches to treating anxiety disorders.