Pancreatic Cancer
Study links sympathetic nerve signaling to early pancreatic cancer growth via a fibroblast feedback loop
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Researchers at Cold Spring Harbor Laboratory report that support cells known as myofibroblastic cancer-associated fibroblasts (myCAFs) can recruit sympathetic nerve fibers into early pancreatic lesions, creating a feedback loop that may help pancreatic cancer take hold before full tumors form. In mouse experiments, disrupting sympathetic nerve activity reduced fibroblast activation and was associated with nearly a 50% reduction in tumor growth.
New research from Yale shows that oleic acid, the main fat in olive oil, accelerated tumor growth in mice prone to pancreatic cancer, while omega-3 fats from fish oil cut disease development by half.
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Scientists at Johns Hopkins Medicine have pinpointed the gene KLF5 as a key driver of pancreatic cancer metastasis through epigenetic changes rather than DNA mutations. Using CRISPR technology, researchers found that KLF5 promotes tumor growth and invasion by altering DNA packaging and activating other cancer-related genes. The findings, published in Molecular Cancer, suggest potential new treatment targets.