Pancreatic Cancer
Study links sympathetic nerve signaling to early pancreatic cancer growth via a fibroblast feedback loop
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Researchers at Cold Spring Harbor Laboratory report that support cells known as myofibroblastic cancer-associated fibroblasts (myCAFs) can recruit sympathetic nerve fibers into early pancreatic lesions, creating a feedback loop that may help pancreatic cancer take hold before full tumors form. In mouse experiments, disrupting sympathetic nerve activity reduced fibroblast activation and was associated with nearly a 50% reduction in tumor growth.
Researchers at Cold Spring Harbor Laboratory have identified key proteins and protein complexes that help certain carcinomas shift their cellular identity and potentially evade treatment. Two new studies, focusing on pancreatic cancer and tuft cell lung cancer, highlight molecular structures that could become targets for more precise and selective therapies.