Parkinson's
UCLA Health study links long-term chlorpyrifos exposure to higher Parkinson’s risk
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A UCLA Health study reports that people with long-term residential exposure to the pesticide chlorpyrifos had more than a 2.5-fold higher likelihood of developing Parkinson’s disease. The research, published in Molecular Neurodegeneration, pairs human exposure estimates with animal and zebrafish experiments that found dopamine-neuron damage and disruptions to the brain’s protein “cleanup” system.
Researchers at Emory University have discovered that excessive brain and muscle activity during minor balance disruptions contributes to poorer balance recovery in older adults, including those with Parkinson's disease. The study, published in eNeuro, reveals that trying harder to balance may actually increase fall risk. Opposing muscles stiffening simultaneously further impairs stability.
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Michael J. Fox guest stars in Shrinking season 3 as Gerry, a Parkinson's patient who befriends Harrison Ford's Paul—sometimes real, sometimes a hallucination. The role reunites Fox with creator Bill Lawrence from Spin City and spotlights Parkinson's challenges.
Researchers at Case Western Reserve University report they have identified an abnormal interaction between the Parkinson’s-linked protein alpha-synuclein and the enzyme ClpP that disrupts mitochondrial function in experimental models. They also describe an experimental compound, CS2, designed to block that interaction, which they say improved movement and cognitive performance and reduced brain inflammation in lab and mouse studies.