ALS
Study links microbial glycogen in the gut to inflammation in C9orf72-associated ALS and frontotemporal dementia
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Researchers at Case Western Reserve University report that some gut bacteria can make unusually inflammatory forms of glycogen and that this microbial glycogen can trigger immune activity linked to brain inflammation in models of disease tied to the C9orf72 mutation. In patient stool samples, the team found these glycogen forms more often in ALS and C9orf72-related frontotemporal dementia than in healthy controls, and enzymatically breaking down glycogen in the gut improved outcomes in mice.
Pierre Deny, the French actor known for his role in Netflix's Emily in Paris, has died at 69 after a battle with ALS.
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Katherine Heigl shared a heartfelt tribute to her former Grey's Anatomy co-star Eric Dane, who passed away at 53 following a battle with ALS. The actress explained her unusual decision to grieve publicly, quoting a Robert Frost poem in her message to Dane's family. Tributes continue to pour in as loved ones launch a GoFundMe for his daughters.