Behavior
Brain protein KCC2 helps shape how cues become habits by modulating dopamine signals
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Researchers at Georgetown University Medical Center report that shifts in the brain protein KCC2 can change how strongly everyday cues become linked to rewards. In a study published December 9 in Nature Communications, they show that reduced KCC2 activity in rats is associated with intensified dopamine neuron firing and stronger cue–reward learning, offering clues to mechanisms that may also be involved in addiction and other psychiatric disorders.
New research shows that everyday sights and sounds can trap some people in harmful choices by influencing their brains through associative learning. Those highly sensitive to these cues struggle to update their responses when outcomes turn negative, leading to persistent risky behavior. The findings, led by Giuseppe di Pellegrino at the University of Bologna, highlight implications for addictions and anxiety.
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A recent study involving over 3,000 dogs has found no link between common genetic variants and behavioral traits, challenging the claims of popular at-home DNA tests. Researchers from the University of Massachusetts analyzed data from the Darwin’s Ark project and concluded that such tests lack predictive accuracy. This finding highlights the complex interplay of genetics and environment in shaping canine personality.