Ferroptosis
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Single GPX4 mutation exposes ferroptosis as driver of early childhood dementia
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Researchers in Germany have identified a rare mutation in the GPX4 enzyme that disables its protective role in neurons, allowing toxic lipid peroxides to damage cell membranes and trigger ferroptotic cell death. Studies in patient-derived cells and mice show a pattern of neurodegeneration that resembles changes seen in Alzheimer’s disease and other dementias.
Researchers at NYU Langone Health report that inhibiting the protein FSP1 induces ferroptosis and markedly slows lung adenocarcinoma in mouse models. The study, published online in Nature on November 5, 2025, found tumor growth reductions of up to 80% in preclinical tests, according to the institution.