Ferroptosis
Single GPX4 mutation exposes ferroptosis as driver of early childhood dementia
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Researchers in Germany have identified a rare mutation in the GPX4 enzyme that disables its protective role in neurons, allowing toxic lipid peroxides to damage cell membranes and trigger ferroptotic cell death. Studies in patient-derived cells and mice show a pattern of neurodegeneration that resembles changes seen in Alzheimer’s disease and other dementias.
Peneliti di NYU Langone Health melaporkan bahwa menghambat protein FSP1 menginduksi ferroptosis dan secara signifikan memperlambat adenocarcinoma paru pada model tikus. Studi tersebut, yang diterbitkan secara online di Nature pada 5 November 2025, menemukan pengurangan pertumbuhan tumor hingga 80% dalam uji praklinis, menurut institusi tersebut.