Parkinson's Disease
South Korean study links cavity-causing mouth bacterium to Parkinson’s-like brain changes in mice
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Researchers in South Korea report evidence that an oral bacterium best known for causing tooth decay can colonize the gut and generate a metabolite that reaches the brain and triggers Parkinson’s-like pathology in mouse experiments. The work, published in Nature Communications, adds to growing evidence that gut microbes and their byproducts may influence neurodegenerative disease processes.
Researchers at McGill University have challenged the conventional understanding of dopamine's function in movement, suggesting it acts more like engine oil than a gas pedal. This discovery, published in Nature Neuroscience, could simplify treatments for Parkinson's disease by focusing on maintaining steady dopamine levels. The findings stem from experiments showing that dopamine enables movement without directly controlling its speed or force.
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Apple TV+'s Shrinking returns for its third season on January 28 with a one-hour premiere, focusing on deeper challenges for its characters. Co-creator Bill Lawrence reveals that Paul’s Parkinson’s disease will worsen, while Jimmy explores new romantic possibilities. The season also introduces notable guest stars including Michael J. Fox and Jeff Daniels.