Abatacept delays rheumatoid arthritis for years after treatment

A one-year course of the drug abatacept can delay the onset of rheumatoid arthritis by up to four years in high-risk individuals. The benefits persisted long after treatment stopped, according to new research from King's College London.

The study, published in The Lancet Rheumatology, followed participants from an earlier trial for four to eight years. Researchers tracked 213 people from the UK and the Netherlands who were at high risk of developing rheumatoid arthritis. Those who received abatacept developed the condition much later than those on placebo, with some delays extending several years beyond the treatment period.

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Illustration of a laboratory rat showing rheumatoid arthritis joint damage before and after plant compound treatment
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Plant-derived compound reduced rheumatoid arthritis-like joint damage in rat study

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A compound called obakulactone eased swelling and tissue damage in a rat model of rheumatoid arthritis and appeared to work by triggering the breakdown of a metabolic enzyme, ACOT1, researchers reported in the journal Engineering.

Promising animal studies from University of Colorado Boulder offer hope for osteoarthritis patients through a single injection that repairs damaged joints in weeks. Affecting one in six people over 30—with no cure—the disease limits daily activities, but this therapy targets root causes beyond pain management or surgery.

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Findings from South Africa's BEAT Tuberculosis study, published in the New England Journal of Medicine, show a new six-month regimen cures 90 percent of drug-resistant TB cases.

South Africa has started rolling out the twice-yearly HIV prevention injection lenacapavir, though success depends on managing interactions with common tuberculosis medicines.

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A small study has found that CAR-T cell therapy may offer a new way to manage HIV over the long term. The approach, already used to treat certain cancers, involves engineering a patient’s own immune cells.

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