Immuno-oncology

Cryo-expansion microscopy captures 3D architecture of killer T cells at the immune synapse, including in human tumors

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Researchers from the University of Geneva and Lausanne University Hospital report they have visualized, in three dimensions and under near-native conditions, how cytotoxic T cells organize their killing machinery at the immune synapse. The work, published in Cell Reports, applies cryo-expansion microscopy to human T cells and to tumor tissue samples, providing nanoscale views intended to support immunology and cancer research.