Alzheimer's Research
Blocking a circadian clock protein boosts brain NAD+ and curbs tau in mice
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Washington University scientists report that inhibiting the circadian regulator REV-ERBα raised brain NAD+ and reduced tau pathology in mouse models, pointing to a clock-focused strategy worth exploring for Alzheimer’s disease.
Johns Hopkins identifies brain nanotubes that may spread Alzheimer’s
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Researchers at Johns Hopkins Medicine have discovered microscopic nanotube channels in the brain that neurons use to transfer toxic molecules, potentially spreading harmful proteins linked to Alzheimer’s disease. The findings, based on experiments with genetically modified mice, suggest these structures increase early in disease models. The study offers new insights into neurodegenerative disorders and possible therapeutic targets.