Alzheimer's Research
Mayo Clinic team uses DNA aptamers to tag senescent ‘zombie’ cells
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Researchers at Mayo Clinic have developed an aptamer-based technique to tag senescent, or so‑called “zombie,” cells in living mouse tissues, work they say could eventually support targeted therapies for age‑related diseases. The project grew out of a chance conversation between two graduate students, according to Mayo Clinic.
Researchers in Germany have identified a rare mutation in the GPX4 enzyme that disables its protective role in neurons, allowing toxic lipid peroxides to damage cell membranes and trigger ferroptotic cell death. Studies in patient-derived cells and mice show a pattern of neurodegeneration that resembles changes seen in Alzheimer’s disease and other dementias.
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A large study published in Neurology finds that impaired kidney function is linked to higher levels of Alzheimer’s biomarkers in the blood, without increasing overall dementia risk. However, among people who already have elevated biomarker levels, poor kidney health may hasten when dementia symptoms appear, underscoring the need to factor kidney function into interpretation of Alzheimer’s blood tests.