底特律老虎队于5月28日在科默里卡公园球场迎战洛杉矶天使队，进行三场系列赛的最后一场比赛。
双方在前两场比赛中各胜一场。洛杉矶天使队在首场比赛中以10-6获胜，底特律老虎队则在次日以4-0扳回一城。格雷森·罗德里格斯（Grayson Rodriguez）担任天使队的先发投手，杰克·弗莱厄蒂（Jack Flaherty）则代表老虎队登板。比赛首球定于美国东部时间下午1点10分投出，底特律老虎队在胜负盘口中以-131的赔率被列为热门方，总分盘口设为8.5分。
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The Los Angeles Angels scored 14 runs and defeated the Tampa Bay Rays 14-3 on Saturday at Tropicana Field. Wade Meckler hit the first grand slam of his career in the first inning.
The Detroit Tigers will host the St. Louis Cardinals for the third game of their interleague series on Sunday Night Baseball at Comerica Park. Both teams hold 4-4 records early in the 2026 MLB season, with Detroit winning the first two contests 4-0 and 11-6. First pitch is set for 7:20 p.m. ET.
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The Chicago White Sox defeated the Detroit Tigers 2-1 on Sunday afternoon at Rate Field to complete a three-game sweep and extend their winning streak to five games.
The Baltimore Orioles were scheduled to take on the Tampa Bay Rays on Wednesday afternoon in a matchup at Tropicana Field. Tampa Bay entered the game in first place in the AL East while Baltimore sat in last.
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The Arizona Diamondbacks secured a 9-6 victory over the Detroit Tigers in their home opener at Chase Field, snapping a rough start to the season. Corbin Carroll drove in key runs with a triple and a three-run homer, while Michael Soroka delivered a strong debut capped by an immaculate inning. A tense seventh inning tested the bullpen, but the Diamondbacks held on for the win before a sellout crowd.
Mike Trout hit a solo home run and reached base four times, powering the Los Angeles Angels to a 3-0 victory over the Houston Astros in their season opener at Daikin Park. Right-hander José Soriano delivered six scoreless innings with seven strikeouts in his first career Opening Day start. The win marked manager Kurt Suzuki's debut.
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José Soriano delivered seven scoreless innings with 10 strikeouts as the Los Angeles Angels secured a 9-6 victory over the Cincinnati Reds in their series finale at Great American Ball Park. The win marked the Angels' first three-game series triumph against Cincinnati since 2016. Soriano improved to 4-0 this season with an ERA of 0.33.