Clinical Trial
Smart water bottles and coaching increased hydration but did not cut kidney stone recurrences, trial finds
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In a two-year U.S. trial of 1,658 adolescents and adults with prior kidney stones, a technology-assisted hydration program modestly increased urine output but did not significantly reduce symptomatic stone recurrences compared with standard care.
A minimally invasive procedure called duodenal mucosal resurfacing may help patients maintain weight loss after discontinuing drugs like Ozempic and tirzepatide. Early results from the REMAIN-1 clinical trial show treated participants regained far less weight than those in a control group after six months off medication. The findings are set for presentation at Digestive Disease Week 2026.
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A randomized, placebo-controlled trial led by Australia’s Garvan Institute of Medical Research found that metformin, a long-used and low-cost drug for type 2 diabetes, did not improve clamp-measured insulin resistance in adults with type 1 diabetes but was associated with roughly 12% lower insulin requirements while blood sugar measures remained broadly unchanged.
In the Cuban province of Matanzas, a clinical trial has begun for the drug Jusvinza, developed by the Center for Genetic Engineering and Biotechnology (CIGB). The medication targets residual polyarthritis in patients recovering from chikungunya. This step represents progress in local healthcare efforts.
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Researchers at Tohoku University report that lubiprostone, a medication commonly used to treat chronic constipation, helped slow the decline of kidney function in patients with chronic kidney disease in a Phase II trial. The findings emerged from work exploring how gut health and constipation influence kidney outcomes.
A new topical serum containing plant extracts and growth proteins has shown promising results in increasing hair density and thickness within 56 days. Developed by researchers in Taiwan, the treatment outperformed a placebo in a small clinical trial involving 60 adults. While encouraging, experts call for larger studies to confirm its efficacy.