Epigenetics
Scientists map proteins that let carcinomas change identity
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Researchers at Cold Spring Harbor Laboratory have identified key proteins and protein complexes that help certain carcinomas shift their cellular identity and potentially evade treatment. Two new studies, focusing on pancreatic cancer and tuft cell lung cancer, highlight molecular structures that could become targets for more precise and selective therapies.
New research suggests sea turtles possess an epigenetic mechanism that helps maintain balanced sex ratios despite rising temperatures from global warming. This adaptation could mitigate fears of population collapse due to excessive female hatchlings. Scientists from Queen Mary University of London led the study on loggerhead turtles.
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An international team has identified an early 'Big Bang' moment in colorectal (bowel) cancer when tumor cells first evade immune surveillance, a finding that could refine who benefits from immunotherapy. The work, funded by Cancer Research UK and the Wellcome Trust, analyzed samples from 29 patients and was published in Nature Genetics on November 5, 2025.