Epigenetics
Scientists map proteins that let carcinomas change identity
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Researchers at Cold Spring Harbor Laboratory have identified key proteins and protein complexes that help certain carcinomas shift their cellular identity and potentially evade treatment. Two new studies, focusing on pancreatic cancer and tuft cell lung cancer, highlight molecular structures that could become targets for more precise and selective therapies.
Scientists at Johns Hopkins Medicine have pinpointed the gene KLF5 as a key driver of pancreatic cancer metastasis through epigenetic changes rather than DNA mutations. Using CRISPR technology, researchers found that KLF5 promotes tumor growth and invasion by altering DNA packaging and activating other cancer-related genes. The findings, published in Molecular Cancer, suggest potential new treatment targets.
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Researchers at the Salk Institute have developed a detailed epigenetic catalog of human immune cells, showing how genetics and life experiences influence immune responses differently. The study, published in Nature Genetics, analyzed samples from 110 diverse individuals to distinguish inherited from environmental epigenetic changes. This work could lead to personalized treatments for infectious diseases.