Epigenetics
Scientists map proteins that let carcinomas change identity
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Researchers at Cold Spring Harbor Laboratory have identified key proteins and protein complexes that help certain carcinomas shift their cellular identity and potentially evade treatment. Two new studies, focusing on pancreatic cancer and tuft cell lung cancer, highlight molecular structures that could become targets for more precise and selective therapies.
A federally funded mouse study has revealed that some inherited traits follow non-Mendelian patterns through epigenetic changes. The research identified hundreds of unexpected DNA methylation events across generations. It also documented the first known natural paramutation in a mammal.
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Scientists at Johns Hopkins Medicine have pinpointed the gene KLF5 as a key driver of pancreatic cancer metastasis through epigenetic changes rather than DNA mutations. Using CRISPR technology, researchers found that KLF5 promotes tumor growth and invasion by altering DNA packaging and activating other cancer-related genes. The findings, published in Molecular Cancer, suggest potential new treatment targets.