Antibiotics
Study links Enterococcus faecalis metabolism to stalled healing in chronic wounds
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Researchers report that Enterococcus faecalis—a bacterium often found in chronic wounds—can hinder skin repair by generating hydrogen peroxide through a metabolic pathway, triggering stress responses that stop key skin cells from migrating. In laboratory experiments, breaking down the peroxide with the antioxidant enzyme catalase helped restore cell movement, suggesting a potential treatment approach that does not rely on antibiotics.
Scientists at the University of Basel have developed a novel testing method to determine whether antibiotics actually eliminate bacteria or merely halt their growth. This approach, called antimicrobial single-cell testing, tracks individual bacteria under a microscope to assess drug effectiveness more accurately. The findings, published in Nature Microbiology, highlight variations in bacterial tolerance to treatments for tuberculosis and other lung infections.
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Results from a global phase 3 trial of zoliflodacin, an investigational single-dose oral antibiotic, were published in The Lancet in December 2025, showing the drug was non-inferior to a ceftriaxone-based standard regimen for curing uncomplicated urogenital gonorrhea in a study of 930 participants across five countries.
Scientists have captured the first detailed images revealing how the common antibiotic rifampicin disrupts E. coli bacteria at a molecular level. Using advanced cryo-electron tomography, researchers visualized the drug binding to bacterial machinery, halting growth. The findings, published in Nature, offer new insights into antibiotic mechanisms.