Antibiotics
Scientists uncover hidden antibiotic intermediate 100-fold more active than methylenomycin A
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Researchers from the University of Warwick and Monash University report that pre-methylenomycin C lactone—an overlooked biosynthetic intermediate from Streptomyces coelicolor—shows more than a 100-fold increase in activity over methylenomycin A against Gram‑positive pathogens, including those behind MRSA and VRE. The finding adds momentum to efforts to tackle antimicrobial resistance, which was directly linked to an estimated 1.27 million deaths in 2019.
Images show rifampicin's effects on E. coli bacteria
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Scientists have captured the first detailed images revealing how the common antibiotic rifampicin disrupts E. coli bacteria at a molecular level. Using advanced cryo-electron tomography, researchers visualized the drug binding to bacterial machinery, halting growth. The findings, published in Nature, offer new insights into antibiotic mechanisms.
WHO reports sharp rise in antibiotic resistance
Antibiotic resistance has surged globally, outpacing treatment options, according to a new World Health Organization report. One in six lab-confirmed bacteria in 2023 resisted antibiotics, linked to common diseases. The trend poses a growing threat to public health.
Researchers uncover new mechanism in bacterial resistance
Scientists have identified a novel protein complex that enables bacteria to evade antibiotic treatments. This discovery, detailed in a recent study, could pave the way for more effective drugs. The findings highlight the evolving challenges in combating antimicrobial resistance.