Antibiotics
Study links Enterococcus faecalis metabolism to stalled healing in chronic wounds
AI에 의해 보고됨 AI에 의해 생성된 이미지 사실 확인됨
Researchers report that Enterococcus faecalis—a bacterium often found in chronic wounds—can hinder skin repair by generating hydrogen peroxide through a metabolic pathway, triggering stress responses that stop key skin cells from migrating. In laboratory experiments, breaking down the peroxide with the antioxidant enzyme catalase helped restore cell movement, suggesting a potential treatment approach that does not rely on antibiotics.
Scientists at the University of Basel have developed a novel testing method to determine whether antibiotics actually eliminate bacteria or merely halt their growth. This approach, called antimicrobial single-cell testing, tracks individual bacteria under a microscope to assess drug effectiveness more accurately. The findings, published in Nature Microbiology, highlight variations in bacterial tolerance to treatments for tuberculosis and other lung infections.
AI에 의해 보고됨 사실 확인됨
Results from a global phase 3 trial of zoliflodacin, an investigational single-dose oral antibiotic, were published in The Lancet in December 2025, showing the drug was non-inferior to a ceftriaxone-based standard regimen for curing uncomplicated urogenital gonorrhea in a study of 930 participants across five countries.
Scientists have captured the first detailed images revealing how the common antibiotic rifampicin disrupts E. coli bacteria at a molecular level. Using advanced cryo-electron tomography, researchers visualized the drug binding to bacterial machinery, halting growth. The findings, published in Nature, offer new insights into antibiotic mechanisms.