Antibiotic Resistance

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Illustration of UC San Diego researchers' CRISPR pPro-MobV system spreading through bacterial biofilms to disable antibiotic resistance genes in a lab setting.
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UC San Diego researchers describe a gene-drive-like CRISPR system designed to reduce antibiotic resistance in bacteria

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Researchers at the University of California San Diego report they have developed a second-generation CRISPR-based “Pro-Active Genetics” system, called pPro-MobV, that is designed to spread between bacteria and disable antibiotic-resistance genes, including inside hard-to-treat biofilms.

Scientists have discovered a 5,000-year-old bacterium in a Romanian ice cave that resists several contemporary antibiotics. The microbe, isolated from permafrost, carries over 100 resistance genes and could inhibit dangerous superbugs. This finding highlights natural evolution of resistance and potential biotechnological applications.

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Researchers in Guatemala's Western Highlands discovered a stark mismatch between public perceptions of drinking water safety and actual contamination levels. Bottled water, widely trusted as the safest option, proved most prone to harmful bacteria, while protected municipal wells emerged as the cleanest sources. The findings, published in the Journal of Water and Health, underscore risks to public health from unsafe water.

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