Antibiotic Resistance
UC San Diego researchers describe a gene-drive-like CRISPR system designed to reduce antibiotic resistance in bacteria
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Researchers at the University of California San Diego report they have developed a second-generation CRISPR-based “Pro-Active Genetics” system, called pPro-MobV, that is designed to spread between bacteria and disable antibiotic-resistance genes, including inside hard-to-treat biofilms.
Researchers at the John Innes Centre have identified a three-gene system that causes bacteria to burst open, releasing virus-like particles that share DNA, including antibiotic resistance genes. The system, called LypABC, resembles a repurposed bacterial immune defense. The findings, published in Nature Microbiology, highlight how bacteria facilitate horizontal gene transfer.
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Scientists have discovered a 5,000-year-old bacterium in a Romanian ice cave that resists several contemporary antibiotics. The microbe, isolated from permafrost, carries over 100 resistance genes and could inhibit dangerous superbugs. This finding highlights natural evolution of resistance and potential biotechnological applications.
A new study indicates that influenza can produce urinary symptoms often mistaken for urinary tract infections, leading to unnecessary antibiotic prescriptions. Researchers analyzed patient data to highlight this overlap during flu season. The findings aim to improve diagnostic accuracy and curb antibiotic resistance.