Rheumatoid Arthritis
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Study maps hidden immune changes years before rheumatoid arthritis symptoms
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A multi-year study has found that rheumatoid arthritis appears to begin years before joint pain or stiffness, with sweeping immune changes unfolding silently in people who carry RA‑linked antibodies. By tracking these at‑risk individuals over seven years, researchers documented systemic inflammation, immune cell dysfunction and epigenetic reprogramming, findings that could support earlier detection and prevention efforts.
A one-year course of the drug abatacept can delay the onset of rheumatoid arthritis by up to four years in high-risk individuals. The benefits persisted long after treatment stopped, according to new research from King's College London.