Rheumatoid Arthritis
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Study maps hidden immune changes years before rheumatoid arthritis symptoms
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A multi-year study has found that rheumatoid arthritis appears to begin years before joint pain or stiffness, with sweeping immune changes unfolding silently in people who carry RA‑linked antibodies. By tracking these at‑risk individuals over seven years, researchers documented systemic inflammation, immune cell dysfunction and epigenetic reprogramming, findings that could support earlier detection and prevention efforts.