Autoimmune Diseases
Stanford dual-transplant therapy prevents and reverses type 1 diabetes in mice
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Stanford Medicine researchers have developed a combined blood stem cell and pancreatic islet cell transplant that, in mice, either prevents or cures type 1 diabetes using tissue from immunologically mismatched donors. The approach creates a hybrid immune system that halts autoimmune attacks without immunosuppressive drugs, and relies on tools already in clinical use, suggesting human trials may be feasible.
A large-scale study reveals that about one in ten people carry genetic variants making them more vulnerable to severe effects from the Epstein-Barr virus, which infects over 90 percent of the population. These variants are linked to higher viral persistence and increased risks of autoimmune diseases like multiple sclerosis and lupus. The findings, based on over 735,000 genomes, suggest pathways for targeted treatments and vaccines.
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The 2025 Nobel prize in physiology or medicine has been awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering a key immune cell that prevents the body from attacking itself. Their work revealed regulatory T-cells and the FOXP3 gene's role in controlling autoimmune responses. This breakthrough has opened new avenues for treating autoimmune diseases and cancers.