HIV
Study links monocyte “biological aging” in blood to emotional depression symptoms in women with and without HIV
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A study of 440 participants from the Women’s Interagency HIV Study found that accelerated epigenetic aging in monocytes—an immune cell type—tracked more closely with emotional and cognitive depression symptoms such as hopelessness and loss of pleasure than with physical symptoms like fatigue. The work, published in The Journals of Gerontology: Series A, adds evidence that cell-type-specific aging measures could contribute to future biological tools to complement symptom-based depression screening, though researchers say more validation is needed before clinical use.
A study published on Monday in Nature Microbiology confirms long-term HIV remission in the «Oslo patient», a 62-year-old man treated for myelodysplasia via stem cell transplant from his brother carrying the CCR5 Delta 32 mutation. He has been off antiretrovirals for four years with no detectable virus. This brings the total to ten patients deemed cured this way.
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Scientists at Scripps Research have developed a nanodisc platform that mimics viral membranes, uncovering hidden interactions in HIV and Ebola proteins that traditional methods miss. The technology allows for more accurate study of antibody responses, potentially accelerating vaccine development. The findings appear in Nature Communications.
The U.S. Food and Drug Administration (FDA) and the European Medicines Agency have approved lenacapavir as pre-exposure prophylaxis (PrEP) for uninfected individuals at high risk. This antiretroviral drug is administered via subcutaneous injections every six months, providing an alternative to daily pills. The World Health Organization endorses its use in comprehensive prevention strategies.
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In Cuba, 35,373 people live with human immunodeficiency virus (HIV), a stable figure due to the effective national program. New diagnoses have dropped by 14.5%, and related deaths by 39%. These gains highlight the Cuban state's commitment to universal health access.