Hypertension
Study links brainstem “lateral parafacial” neurons to a form of hypertension in rats
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Researchers working with the University of Auckland and Brazil’s University of São Paulo report that neurons in the medulla’s lateral parafacial (pFL) region—best known for helping drive forceful exhalations—also amplify sympathetic nerve activity and can raise blood pressure in an animal model of neurogenic hypertension. Inhibiting these neurons lowered blood pressure toward normal in hypertensive rats, findings published in Circulation Research.
A new genetic study indicates that obesity and high blood pressure directly contribute to dementia, beyond merely raising its risk. Researchers from Denmark and the U.K. used advanced methods to establish this causal link, emphasizing prevention through weight and blood pressure management. The findings suggest early interventions could avert vascular-related dementia.
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A new study from Weill Cornell Medicine reveals that hypertension begins harming the brain early, disrupting blood vessels, neurons, and white matter before blood pressure increases. These changes, observed in mice, may explain the link between hypertension and cognitive disorders like Alzheimer's. The research, published on November 14 in Neuron, suggests potential benefits from medications like losartan.