Chinese researchers develop super antibody for deadly SFTS

Researchers in China have developed a potent antibody that could combat severe fever with thrombocytopenia syndrome (SFTS), a tick-borne disease with a mortality rate of up to 30 percent. The discovery offers new hope for tackling this growing threat in East Asia.

In the world of tick-borne illnesses, Lyme disease grabs the headlines. For example, Greg Yang, one of the 12 original co-founders of Elon Musk’s artificial intelligence startup xAI, said in late January that he was stepping back from the company after being diagnosed with the disease, noting that accidentally eating the wrong food would leave him “extremely tired,” requiring days to recover.

But there is a more dangerous condition transmitted by ticks that a team at a Chinese university might now have a way to treat. The syndrome, severe fever with thrombocytopenia syndrome (SFTS), caused by the Dabie bandavirus and spread by the Haemaphysalis longicornis tick, has a mortality rate of up to 30 percent. It was first identified in 2009 during investigations into cases of a then-unknown illness involving a sudden rise in body temperature.

The researchers said the discovery could “open up new avenues” for tackling the growing threat posed by ticks. This ‘super antibody’ represents a potential breakthrough in addressing the parasitic danger, particularly in East Asia, including China, Japan, and South Korea.

The development highlights the increasing global attention to tick-borne diseases, from Europe and North America to Australia and New Zealand. The team is based in Hangzhou, underscoring local innovation's role in public health challenges.

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Illustration of Australian scientists developing antibodies targeting bacteria-specific sugar to treat drug-resistant infections in mice.
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Australian team develops antibodies targeting a bacteria-only sugar, clearing drug-resistant infection in mice

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Australian researchers report they have engineered monoclonal antibodies that recognize pseudaminic acid—a sugar made by bacteria but not by humans—and used them to help eliminate multidrug-resistant Acinetobacter baumannii infections in mice, a step toward potential passive-immunotherapy treatments for hard-to-treat hospital infections.

Researchers from Australia have reported positive results from a Phase II clinical trial of a new carbohydrate-based drug for treating sepsis. The trial, involving 180 patients in China, demonstrated the drug's ability to reduce the condition's severity. This development offers hope for the first targeted therapy against a leading cause of global deaths.

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Scientists have harvested antibodies from the blood of paediatricians to develop new preventative treatments for respiratory syncytial virus (RSV) and human metapneumovirus. These antibodies outperform existing therapies by up to 25 times and target a wider range of strains. The discovery stems from the natural immunity built by paediatricians through years of exposure to respiratory viruses.

Scientists have created innovative nanoparticles designed to destroy harmful proteins linked to dementia and cancer. These particles can access difficult tissues like the brain and precisely eliminate problematic proteins without broad side effects. The technology shows early promise for precision medicine.

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Scientists at Northwestern Medicine have developed an antibody that counters pancreatic cancer's sugar-based disguise, enabling the immune system to attack tumors more effectively. In mouse studies, the therapy slowed tumor growth by restoring immune activity. The team is preparing the antibody for human trials.

Researchers at Oregon Health & Science University have pinpointed specific sites on NMDA receptors targeted by harmful antibodies in a rare autoimmune brain disorder known as "Brain on Fire." This discovery, published in Science Advances, could lead to more precise treatments and earlier detection. The condition affects about 1 in 1 million people annually, mainly young adults, causing severe symptoms like seizures and memory loss.

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Researchers at Stanford Medicine have created an experimental nasal spray vaccine that protects mice against multiple respiratory threats, including COVID-19, flu, bacterial pneumonia, and allergens. The vaccine activates the lungs' innate immune system for months, offering broad defense without targeting specific pathogens. Published in Science on February 19, the study suggests potential for human trials soon.

 

 

 

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