Circadian Rhythm
Weaker circadian “body clocks” in older adults tied to higher dementia risk, study finds
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Older adults with weaker or more irregular daily rest-activity rhythms were more likely to be diagnosed with dementia over about three years, according to a study published in *Neurology*. The research also linked later-afternoon activity peaks to higher dementia risk, though it did not establish that disrupted circadian rhythms cause dementia.
Research indicates that inducing labor between 3am and 9am aligns with natural circadian rhythms, potentially reducing labor duration and the need for emergency Caesarean sections. This approach, based on a study of over 3,000 cases in Michigan, offers a simple way to improve outcomes for mothers and babies without added risks. Experts suggest prioritizing first-time mothers and those with higher body mass index for these timings.
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Washington University scientists report that inhibiting the circadian regulator REV-ERBα raised brain NAD+ and reduced tau pathology in mouse models, pointing to a clock-focused strategy worth exploring for Alzheimer’s disease.