Circadian Rhythm
Immagine generata dall'IA
Weaker circadian “body clocks” in older adults tied to higher dementia risk, study finds
Riportato dall'IA Immagine generata dall'IA Verificato
Older adults with weaker or more irregular daily rest-activity rhythms were more likely to be diagnosed with dementia over about three years, according to a study published in *Neurology*. The research also linked later-afternoon activity peaks to higher dementia risk, though it did not establish that disrupted circadian rhythms cause dementia.
Washington University scientists report that inhibiting the circadian regulator REV-ERBα raised brain NAD+ and reduced tau pathology in mouse models, pointing to a clock-focused strategy worth exploring for Alzheimer’s disease.