Chronic Pain
Genetic studies uncover variants linked to fibromyalgia risk
Two large-scale genetic studies involving millions of participants have identified variants associated with fibromyalgia, supporting the role of central nervous system dysfunction in the chronic pain condition. The research highlights genes involved in neuronal function and brain-related issues. While promising, experts note the findings are preliminary and point to multifaceted causes.
Scientists uncover brain circuit that overrides chronic pain
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Researchers at the University of Pennsylvania have identified a group of brainstem neurons that can suppress chronic pain signals when survival needs like hunger or fear arise. These Y1 receptor neurons in the lateral parabrachial nucleus act as a neural switchboard, prioritizing urgent biological demands over persistent discomfort. The discovery, published in Nature, offers potential new avenues for pain treatments.