デレク・シェパード医師の退場は、彼の死から数年が経った今も『グレイズ・アナトミー』に影響を与え続けている。
この長寿医療ドラマは、シーズン11でデレクがトラック事故の末に亡くなったことで、中心人物の一人を失った。本作は、デレクとメレディス・グレイの関係性を軸に初期の成功を築き上げてきており、その中にはシーズン5での付箋の誓いや子供たちとの家庭生活も含まれていた。
デレク・シェパードの降板は『グレイズ・アナトミー』にとって今なお最大の損失である
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