Uppsala professor warns TBE vaccine may need updating

TBE cases in Sweden have tripled over ten years despite rising vaccinations. Åke Lundkvist, professor of virology at Uppsala University, suspects the virus may have changed, reducing vaccine effectiveness. Researchers are now analyzing 12,000 ticks to investigate.

The number of reported TBE cases in Sweden has risen sharply over the past ten years. According to Folkhälsomyndigheten, cases increased from 238 in 2016 to 504 in 2025, with peaks like 595 in 2023 and a low of 274 in 2020. Vaccinations have risen at a similar pace.

Åke Lundkvist, professor of virology at Uppsala University, describes the trend as suspicious. "Something is fishy," he told SVT Nyheter. He suggests the vaccine may be losing effectiveness if the TBE virus has mutated. "The vaccine can become less effective if the virus causing the infection changes," Lundkvist explained.

To clarify, around 12,000 ticks collected by the Swedish public are being sent to Statens veterinärmedicinska anstalt (SVA). They will be analyzed in collaboration with Uppsala University's Zoonoscentret to compare current virus strains with those from previous years and the basis for existing vaccines.

Lundkvist stresses the need for vaccination. "Absolutely not [skip getting vaccinated], the vaccine works and it is the only important remedy we have today. We will find out if it can be even better," he said. The research aims to rule out other causes for the rise.

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Realistic image of a person checking for ticks in a Swedish forest with TBE case statistics overlay
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TBE cases rise sharply in Sweden this year

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The number of TBE cases has risen sharply this summer. By July 20, 213 people had been infected, compared with fewer cases in the same period in previous years.

TBE remains a major issue in Örebro County where at least ten people have been affected this year. Despite offering the cheapest vaccine in all of Sweden, far from everyone gets vaccinated.

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A new national survey shows that 37 percent of farmers and 32 percent of forest workers have not been vaccinated against TBE.

The Health Ministry temporarily suspended vaccination with the Butantan Institute's vaccine after recording 42 cases of serious adverse reactions, including three severe cases and two deaths under investigation.

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A needle-free, DNA-based vaccine candidate designed using machine-learning methods has completed a first-in-human Phase 1 study in the UK, with researchers reporting it was well tolerated and induced immune responses against multiple viruses in the sarbecovirus group, which includes SARS-CoV, SARS-CoV-2 and related bat coronaviruses.

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