Biochemistry
Mayo Clinic team uses DNA aptamers to tag senescent ‘zombie’ cells
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Researchers at Mayo Clinic have developed an aptamer-based technique to tag senescent, or so‑called “zombie,” cells in living mouse tissues, work they say could eventually support targeted therapies for age‑related diseases. The project grew out of a chance conversation between two graduate students, according to Mayo Clinic.
Researchers have achieved the most detailed imaging yet of chromatin condensates, revealing how DNA fibers fold and interact within these droplet-like structures. The findings link molecular arrangements to the overall behavior of these condensates in cells. This work builds on earlier discoveries about DNA packing mechanisms.
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A new mathematical analysis by Robert G. Endres of Imperial College London suggests that the spontaneous emergence of life from nonliving matter on early Earth was far less likely than previously thought. Using information theory, the research highlights the immense improbability of assembling a simple protocell from basic chemicals. The findings underscore ongoing challenges in explaining life's origins through natural processes alone.