Biochemistry
Mayo Clinic team uses DNA aptamers to tag senescent ‘zombie’ cells
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Researchers at Mayo Clinic have developed an aptamer-based technique to tag senescent, or so‑called “zombie,” cells in living mouse tissues, work they say could eventually support targeted therapies for age‑related diseases. The project grew out of a chance conversation between two graduate students, according to Mayo Clinic.
Researchers at The University of Osaka have developed ultra-small pores in silicon nitride membranes that approach the scale of natural ion channels. These structures enable repeatable opening and closing through voltage-controlled chemical reactions. The advance could aid DNA sequencing and neuromorphic computing.
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Researchers have achieved the most detailed imaging yet of chromatin condensates, revealing how DNA fibers fold and interact within these droplet-like structures. The findings link molecular arrangements to the overall behavior of these condensates in cells. This work builds on earlier discoveries about DNA packing mechanisms.