Genomics
Ancient DNA ties paratyphoid and relapsing fevers to Napoleon’s 1812 retreat
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Scientists analyzing DNA from 13 soldiers buried in a mass grave in Vilnius, Lithuania, uncovered genetic traces of paratyphoid fever and louse-borne relapsing fever—offering the first direct confirmation of these pathogens in Napoleon’s Grande Armée. The study, published October 24, 2025, in Current Biology, links centuries-old eyewitness reports to modern genomics. ([sciencedaily.com](https://www.sciencedaily.com/releases/2025/10/251026021727.htm))
A new genomic analysis suggests that Alzheimer's disease may begin with inflammation in organs like the skin, lungs, or gut, potentially decades before brain symptoms appear. Researchers analyzed genetic data from hundreds of thousands of people and found risk genes more active outside the brain. This perspective could reshape prevention and treatment strategies.
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Researchers have developed a genomic mapping technique that reveals how thousands of genes work together to influence disease risk, helping to bridge gaps left by traditional genetic studies. The approach, described in a Nature paper led by Gladstone Institutes and Stanford University scientists, combines large-scale cell experiments with population genetics data to highlight promising targets for future therapies and deepen understanding of conditions such as blood disorders and immune-mediated diseases.