의학 연구.
Study identifies SLAMF6 as a self-activating brake on anti-cancer T cells, pointing to a new immunotherapy target
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A research team led by Université de Montréal immunologist André Veillette reports that the immune receptor SLAMF6 can inhibit T cells by activating through interactions on the T cell surface itself, a mechanism the authors say could help explain why some patients fail to respond—or later stop responding—to checkpoint-based cancer immunotherapies. In the same study, the researchers describe monoclonal antibodies designed to block SLAMF6’s self-interaction, which boosted T-cell activity in laboratory tests and strengthened anti-tumor responses in mouse experiments.
A copper-based drug has shown potential to reduce toxic protein buildup and improve memory in laboratory models of Alzheimer’s disease. Researchers at Monash University found that the compound Cu(ATSM) enhanced the brain’s waste-clearing mechanisms. The results were published in ACS Chemical Neuroscience.
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Chess featured prominently at a clinical symposium on Brain-Computer Interface technology held in Shenzhen. FIDE Treasurer Zhu Chen attended the event, highlighting the game's potential in advancing medical research.
A study of 440 participants from the Women’s Interagency HIV Study found that accelerated epigenetic aging in monocytes—an immune cell type—tracked more closely with emotional and cognitive depression symptoms such as hopelessness and loss of pleasure than with physical symptoms like fatigue. The work, published in The Journals of Gerontology: Series A, adds evidence that cell-type-specific aging measures could contribute to future biological tools to complement symptom-based depression screening, though researchers say more validation is needed before clinical use.
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Engineers at Washington University in St. Louis report that while single abnormal cells can mechanically probe roughly 10 microns beyond what they directly touch, groups of epithelial cells can combine forces through collagen to sense features more than 100 microns away—an effect the researchers say could help explain how cancer cells navigate tissue.
한 연구에 따르면, 진행성 폐암 환자가 하루 중 일찍 면역화학요법을 받으면 생존 기간이 더 길다. 홍콩 의료 전문가는 이 발견이 최적 치료 시간을 모색할 가능성을 열었으나 더 많은 연구가 필요하다고 말했다. 이 연구는 중국 본토 후난 암병원의 학자들이 주도했으며 홍콩 중문대 의학부가 지원했다.
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Researchers in Brazil have uncovered how pancreatic cancer uses a protein called periostin to invade nerves and spread early. This discovery explains the disease's aggressiveness and suggests new treatment targets. The findings, published in Molecular and Cellular Endocrinology, highlight the tumor's ability to remodel surrounding tissue.
Researchers test electricity-based method to reshape the cornea for vision correction
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