Medical Research
Longer continuous walks linked to sharply lower heart risk, study finds
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Walking in bouts of 10–15 minutes or longer was associated with substantially lower cardiovascular risk among adults taking fewer than 8,000 steps a day, with 15‑minute‑plus bouts tied to about a two‑thirds lower risk than very short walks, according to research published in Annals of Internal Medicine.
Neurons use fat—not just sugar—for energy, study ties pathway to rare brain disorder
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Researchers in Australia and Finland report that neurons can fuel themselves with fat as well as sugar, challenging long‑held assumptions about brain energy. The discovery, published in Nature Metabolism, links a lipid‑processing enzyme to a rare hereditary spastic paraplegia and suggests that targeted fatty acid supplements may restore cellular energy in laboratory models.
Cellular switch discovery offers hope for Parkinson's treatment
Scientists have identified a key cellular regulator called PP2A-B55alpha that balances mitochondrial health, potentially leading to new therapies for Parkinson's disease. In preclinical models, reducing its activity improved motor symptoms and mitochondrial function. The findings, published in Science Advances, could extend to other mitochondrial disorders and cancer.
Study links menopause to brain structural changes
A new review of studies shows that menopause causes measurable changes in brain structure, including shrinkage in areas key to memory and thinking. These alterations may explain symptoms like brain fog, but evidence suggests some recovery after menopause. The findings will be presented at The Menopause Society's 2025 annual meeting in Orlando.
Drug combo cuts prostate cancer death risk by over 40 percent
A combination of enzalutamide and hormone therapy has reduced the risk of death by more than 40% in men with recurring prostate cancer, according to a major clinical trial. The study, involving over 1,000 patients worldwide, was led by researchers at Cedars-Sinai and presented at a medical congress in Berlin. Experts describe the findings as a game changer for treating aggressive cases.
Weaponised CAR T-cell therapy eradicates prostate tumours in mice
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Researchers directly visualize alpha‑synuclein oligomers in human Parkinson’s brain tissue
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Scientists in the U.K. and Canada report the first direct visualization and measurement of alpha‑synuclein oligomers—the small protein clusters long suspected of triggering Parkinson’s—in human brain tissue. Using an ultra‑sensitive imaging method, the team found these clusters were larger and more numerous in Parkinson’s than in age‑matched controls, a result published in Nature Biomedical Engineering that may help guide earlier diagnosis and targeted therapies.
Glioblastoma erodes skull and disrupts immune system, study reveals
Researchers have discovered that glioblastoma, the most aggressive form of brain cancer, extends beyond the brain by eroding the skull and altering the immune cells in skull marrow. This interaction fuels the cancer's progression and explains why current treatments often fail. The findings, published in Nature Neuroscience, suggest new strategies targeting both brain and bone.
New blood test detects HPV-linked cancers up to 10 years early
Researchers at Mass General Brigham have developed HPV-DeepSeek, a highly sensitive blood test that identifies HPV-associated head and neck cancers nearly a decade before symptoms appear. The test uses whole-genome sequencing to detect viral DNA fragments in the bloodstream. This advance could enable earlier treatments and improve patient outcomes.
Drug combination slows progression of aggressive prostate cancer
A phase III trial has shown that adding niraparib to standard prostate cancer therapy significantly delays disease progression in men with specific DNA repair gene mutations. The AMPLITUDE study, involving 696 men across 32 countries, reported a 37% reduced risk of cancer growth overall and 48% in BRCA-mutated cases. This marks a step toward precision medicine for advanced prostate cancer.
Immune protein promotes arrhythmias after heart attacks
Researchers at Massachusetts General Hospital have identified an immune protein that damages heart cells after a myocardial infarction, leading to dangerous arrhythmias. By targeting this protein in mice, the team reduced arrhythmia incidents twelvefold. The findings suggest new ways to prevent sudden cardiac death.
Nicotinamide reduces skin cancer risk in veterans study
A large Veterans Affairs study has shown that nicotinamide, a form of vitamin B3, can significantly lower the risk of new skin cancers among patients with a history of the disease. The research, involving over 33,000 veterans, found a 14% overall risk reduction, with even greater benefits for early users. These findings build on a 2015 clinical trial and may influence preventive strategies.
Toxic alliance of proteins may trigger Alzheimer's disease
Researchers at Rockefeller University have identified a harmful interaction between amyloid beta and fibrinogen that forms stubborn clots, damaging brain blood vessels and sparking inflammation even at low concentrations. This complex disrupts the blood-brain barrier and leads to early signs of neurodegeneration. The findings suggest a new target for early intervention in Alzheimer's disease.