Medical Research

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Illustration showing 'skinny fat' and high pancreatic fat patterns linked to accelerated brain aging in MRI scans.
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Study links two hidden body-fat patterns to faster brain aging

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Where fat is stored in the body—not only how much—is linked to brain structure and cognition, according to a large MRI study of nearly 26,000 UK Biobank participants. Researchers reported that two fat distribution profiles—one marked by high pancreatic fat and another often described as “skinny fat,” with high fat relative to muscle despite a less-obese appearance—were associated with gray-matter loss, faster brain aging and poorer cognitive outcomes.

Researchers in Brazil have uncovered how pancreatic cancer uses a protein called periostin to invade nerves and spread early. This discovery explains the disease's aggressiveness and suggests new treatment targets. The findings, published in Molecular and Cellular Endocrinology, highlight the tumor's ability to remodel surrounding tissue.

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A small clinical trial shows that faecal microbiota transplants can improve outcomes for kidney cancer patients on immunotherapy drugs. Participants receiving transplants experienced longer cancer stability and greater tumor shrinkage compared to those given placebos. The approach targets the gut microbiome to boost immune responses against tumors.

Researchers have shown how mutations in key actin genes can lead to abnormally small brains in children with Baraitser–Winter syndrome. Using lab-grown human brain organoids, the team found that these mutations alter the orientation of early brain progenitor cell divisions and deplete crucial stem cell populations, providing a cellular mechanism for the syndrome‑associated microcephaly.

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A study of professional female football players suggests that injuries sustained during menstruation lead to longer recovery times. Researchers found that while injury rates do not increase during periods, the injuries appear more severe. This finding highlights potential hormonal influences on athletic recovery.

A Mount Sinai–led study finds that commonly used heart-attack risk calculators and symptom-based screening fail to identify nearly half of people who will soon experience a first heart attack. The brief report, published November 21 in JACC: Advances, underscores limitations in current prevention strategies and argues for earlier imaging to detect silent plaque.

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Researchers at Baylor College of Medicine report that raising levels of the protein Sox9 in astrocytes enables these brain support cells to remove existing amyloid plaques and preserve cognitive performance in mouse models of Alzheimer’s disease that already show memory deficits. The findings, published in Nature Neuroscience, highlight astrocytes as a potential target for slowing neurodegenerative decline.

 

 

 

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