Medical Research
Cells can sense 10 times farther than expected, a finding that may shed light on cancer spread
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Engineers at Washington University in St. Louis report that while single abnormal cells can mechanically probe roughly 10 microns beyond what they directly touch, groups of epithelial cells can combine forces through collagen to sense features more than 100 microns away—an effect the researchers say could help explain how cancer cells navigate tissue.
Researchers from Flinders University and Flinders Medical Centre, reviewing more than 8,400 colonoscopy records, reported that people found to have both adenomas and serrated polyps had up to a fivefold higher risk of developing advanced precancerous colorectal changes at follow-up than those with only one polyp type.
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A study in Molecular Psychiatry used PET imaging with a new tracer to track changes in AMPA-type glutamate receptors in people with treatment-resistant depression receiving ketamine, reporting that region-specific receptor changes were associated with symptom improvement.
An implanted device that stimulates the vagus nerve was associated with sustained improvements in symptoms, functioning and quality of life among adults with long-standing, treatment-resistant major depression, according to researchers reporting two-year follow-up data from the ongoing RECOVER study led by Washington University School of Medicine in St. Louis.
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Researchers at the University of Southampton have created a new class of antibodies designed to strengthen the immune system's attack on cancer cells. These antibodies cluster receptors on T cells to amplify activation signals that tumors typically weaken. Early laboratory tests indicate they outperform standard antibodies in mobilizing cancer-killing immune cells.
Researchers have shown how mutations in key actin genes can lead to abnormally small brains in children with Baraitser–Winter syndrome. Using lab-grown human brain organoids, the team found that these mutations alter the orientation of early brain progenitor cell divisions and deplete crucial stem cell populations, providing a cellular mechanism for the syndrome‑associated microcephaly.
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A study of professional female football players suggests that injuries sustained during menstruation lead to longer recovery times. Researchers found that while injury rates do not increase during periods, the injuries appear more severe. This finding highlights potential hormonal influences on athletic recovery.
UCLA study finds five-day accelerated TMS schedule performed similarly to conventional six-week course for treatment-resistant depression
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