A new study reveals that the MYC protein does more than drive tumor growth. It also repairs DNA damage in cancer cells, allowing some tumors to survive chemotherapy and radiation.
Researchers at Oregon Health & Science University found that MYC moves to sites of broken DNA and recruits repair proteins. This nontraditional role helps tumor cells recover from treatments meant to destroy them, according to senior author Rosalie Sears.
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Researchers say they have identified a cellular mechanism that may help explain why PARP inhibitors can affect tumor cells unevenly: in lab-grown slices of human ovarian tumors, some of these drugs accumulated inside lysosomes, forming slow-release stores that created patchy drug distribution across tissue and even between neighboring cells. The findings were reported in a 2026 paper in Nature Communications.
Researchers at UCLA have identified a protein that slows muscle repair in aging but enhances cell survival in mice. Blocking the protein improved healing speed in older mice, though it reduced long-term stem cell resilience. The findings suggest aging involves survival strategies rather than mere decline.
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A new study has revealed over 200 metabolic enzymes attached directly to human DNA inside the cell nucleus, challenging traditional views of cellular processes. These enzymes form unique patterns in different tissues and cancers, described as a 'nuclear metabolic fingerprint.' The discovery suggests links between metabolism and gene regulation that may influence cancer development and treatment.