En ny studie visar att proteinet MYC gör mer än att bara driva tumörtillväxt. Det reparerar även DNA-skador i cancerceller, vilket gör att vissa tumörer kan överleva kemoterapi och strålning.
Forskare vid Oregon Health & Science University fann att MYC förflyttar sig till platser med skadat DNA och rekryterar reparationsproteiner. Denna okonventionella roll hjälper tumörceller att återhämta sig från behandlingar som är avsedda att förgöra dem, enligt senior författare Rosalie Sears.
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Researchers say they have identified a cellular mechanism that may help explain why PARP inhibitors can affect tumor cells unevenly: in lab-grown slices of human ovarian tumors, some of these drugs accumulated inside lysosomes, forming slow-release stores that created patchy drug distribution across tissue and even between neighboring cells. The findings were reported in a 2026 paper in Nature Communications.
Researchers at UCLA have identified a protein that slows muscle repair in aging but enhances cell survival in mice. Blocking the protein improved healing speed in older mice, though it reduced long-term stem cell resilience. The findings suggest aging involves survival strategies rather than mere decline.
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A new study has revealed over 200 metabolic enzymes attached directly to human DNA inside the cell nucleus, challenging traditional views of cellular processes. These enzymes form unique patterns in different tissues and cancers, described as a 'nuclear metabolic fingerprint.' The discovery suggests links between metabolism and gene regulation that may influence cancer development and treatment.