Styvare cancerceller ökar effekten av CAR-T-cellterapi hos möss

Forskare har upptäckt att genom att göra cancerceller styvare kan man förbättra effekten av CAR-T-cellterapi mot aggressiva tumörer. I experiment på möss ledde metoden i vissa fall till att tumörerna försvann helt. Resultaten presenterades nyligen vid en konferens i London.

Cancerceller är ofta mjukare än friska celler på grund av högre kolesterolnivåer i sina membran. Denna mjukhet kan hjälpa dem att undgå immunförsvarets attacker. Forskare vid Swiss Federal Institute of Technology i Lausanne testade om en förstyvning av dessa celler kunde förbättra resultaten av immunterapi.

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