Enrijecer células cancerígenas potencializa a terapia com células CAR-T em camundongos

15 de maio de 2026

Reportado por IA

Pesquisadores descobriram que tornar as células cancerígenas mais rígidas pode aumentar a eficácia da terapia com células CAR-T contra tumores agressivos. Em experimentos com camundongos, a abordagem levou ao desaparecimento completo do tumor em alguns casos. As descobertas foram apresentadas recentemente em uma conferência em Londres.

As células cancerígenas costumam ser mais macias que as saudáveis devido a níveis mais elevados de colesterol em suas membranas. Essa maciez pode ajudá-las a escapar de ataques imunológicos. Cientistas do Instituto Federal de Tecnologia de Lausanne, na Suíça, testaram se o enrijecimento dessas células poderia melhorar os resultados da imunoterapia.

McGill researchers use reversible drug approach to boost natural killer cells against hard-to-treat cancers

25 de maio de 2026 Reportado por IA Imagem gerada por IA Verificado

Researchers at McGill University report a drug-based method to temporarily enhance natural killer (NK) cells—an immune cell type—by inhibiting two proteins, improving the cells’ ability to attack several aggressive cancers in preclinical experiments.

3D-printed structures could speed up car t-cell therapy

Researchers have developed 3D-printed gels that mimic lymph nodes to improve the production of CAR T-cells for cancer treatment. The approach increased success rates and sped up cell growth compared with standard methods. It may help lower costs and expand access to the therapy worldwide.

Protein found to limit CAR T-cell therapy effectiveness

02 de junho de 2026 Reportado por IA

A protein called NFIL3 has been identified as a key factor in reducing the long-term performance of CAR T cells used in cancer treatment. Researchers showed that disabling this protein allows the engineered cells to remain active longer and fight tumors more effectively in laboratory models.

Health

segunda-feira, 29 de junho de 2026, 21:11h

Enrijecer células cancerígenas potencializa a terapia com células CAR-T em camundongos

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