Skin Cancer
Lower-dose ipilimumab regimen linked to better melanoma outcomes in Swedish study
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Researchers at Karolinska Institutet report that using a reduced dose of ipilimumab together with nivolumab in immunotherapy for advanced malignant melanoma was associated with better tumor control and fewer serious side effects than the traditional full-dose combination. In a real-world study of nearly 400 patients with advanced, inoperable skin cancer, response rates and survival times were higher in the lower-dose group, according to results published in the Journal of the National Cancer Institute.
A new study reports that using tanning beds is associated with nearly triple the risk of melanoma and with pervasive DNA damage across the skin, including in areas that are usually protected from the sun. Researchers from Northwestern University and the University of California, San Francisco, examined medical records and carried out genomic analyses to reach these conclusions. The findings, published on December 12 in Science Advances, are prompting calls for stronger public health warnings against indoor tanning.
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A large Veterans Affairs study has shown that nicotinamide, a form of vitamin B3, can significantly lower the risk of new skin cancers among patients with a history of the disease. The research, involving over 33,000 veterans, found a 14% overall risk reduction, with even greater benefits for early users. These findings build on a 2015 clinical trial and may influence preventive strategies.