Cell Biology
Researchers redefine how key motor protein helps chromosomes align
Von KI berichtet Bild generiert von KI Fakten geprüft
Researchers at the Ruđer Bošković Institute in Zagreb report that the protein CENP-E plays a crucial role in stabilizing the earliest attachments between chromosomes and microtubules during cell division, rather than mainly acting as a motor that pulls chromosomes into place. The work, described in two studies in Nature Communications, revises long-standing models of chromosome congression by linking CENP-E’s function to Aurora kinases and suggesting implications for understanding diseases marked by chromosome segregation errors.
Scientists have proposed a theoretical model explaining how living cells could produce their own electrical signals through tiny movements in their membranes. This mechanism, driven by active molecular processes, might mimic neuronal activity and influence ion transport. The findings could inform bio-inspired materials and deepen understanding of cellular functions.
Von KI berichtet
Researchers have achieved the most detailed imaging yet of chromatin condensates, revealing how DNA fibers fold and interact within these droplet-like structures. The findings link molecular arrangements to the overall behavior of these condensates in cells. This work builds on earlier discoveries about DNA packing mechanisms.
Researchers have discovered that cancer cells respond to physical squeezing by rapidly deploying mitochondria to the nucleus, delivering a burst of ATP to repair DNA damage and ensure survival. This mechanism, observed in lab experiments and patient biopsies, could inspire new strategies to halt cancer spread. The finding redefines mitochondria's role as dynamic responders rather than static energy sources.