Regenerative Medicine
Stem cell ‘pain sponge’ therapy shows promise for osteoarthritis relief and joint protection
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SereNeuro Therapeutics has reported promising preclinical data for SN101, an induced pluripotent stem cell-based therapy for chronic osteoarthritis pain. The treatment uses engineered peripheral pain-sensing neurons that sequester inflammatory pain factors without transmitting pain signals, while releasing regenerative molecules that may help preserve cartilage, according to data presented at an International Society for Stem Cell Research symposium.
Thin sheets made from dried human placentas are showing promise in helping wounds heal with less scarring, based on studies in mice and human patients. These dressings, derived from the amniotic membrane, contain natural growth factors that promote better recovery. Researchers highlight their potential for treating surgical and chronic wounds, though more clinical trials are needed.
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Scientists at Cedars-Sinai Medical Center have developed an experimental synthetic RNA drug called TY1 that strengthens the body’s ability to clear damaged DNA and promote tissue healing. Described in a paper in Science Translational Medicine, the treatment could improve recovery from heart attacks and certain inflammatory or autoimmune conditions by enhancing the activity of a key DNA-processing gene in immune cells.