Gene Mutation
Image générée par IA
Single GPX4 mutation exposes ferroptosis as driver of early childhood dementia
Rapporté par l'IA Image générée par IA Vérifié par des faits
Researchers in Germany have identified a rare mutation in the GPX4 enzyme that disables its protective role in neurons, allowing toxic lipid peroxides to damage cell membranes and trigger ferroptotic cell death. Studies in patient-derived cells and mice show a pattern of neurodegeneration that resembles changes seen in Alzheimer’s disease and other dementias.