Gene Mutation

Single GPX4 mutation exposes ferroptosis as driver of early childhood dementia

Selasa, 09 Desember 2025 Dilaporkan oleh AI Gambar dihasilkan oleh AI Fakta terverifikasi

Researchers in Germany have identified a rare mutation in the GPX4 enzyme that disables its protective role in neurons, allowing toxic lipid peroxides to damage cell membranes and trigger ferroptotic cell death. Studies in patient-derived cells and mice show a pattern of neurodegeneration that resembles changes seen in Alzheimer’s disease and other dementias.