Gene Mutation

Single GPX4 mutation exposes ferroptosis as driver of early childhood dementia

09 de dezembro de 2025 Reportado por IA Imagem gerada por IA Verificado

Researchers in Germany have identified a rare mutation in the GPX4 enzyme that disables its protective role in neurons, allowing toxic lipid peroxides to damage cell membranes and trigger ferroptotic cell death. Studies in patient-derived cells and mice show a pattern of neurodegeneration that resembles changes seen in Alzheimer’s disease and other dementias.