Cambridge study reveals potential to reverse nerve damage

Researchers at the University of Cambridge have developed miniature lab-grown models of the human brain and spinal cord that show damaged nerve fibers can regain the ability to regrow under certain conditions.

The team built functional neural circuits using stem cell-derived organoids kept physically apart in the lab. Axons from brain tissue grew across the gap to connect with spinal cord tissue and trigger muscle contractions. This setup allowed study of regeneration over more than a year of development.

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Illustration of mitochondria transferring from glia to neurons to reduce nerve pain in neuropathy models.
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Duke-led Nature study links glia-to-neuron mitochondria transfer to reduced nerve pain in neuropathy models

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Duke University researchers report that boosting the transfer of healthy mitochondria from support cells to sensory neurons reduced pain-like behaviors in mouse models of diabetic and chemotherapy-related peripheral neuropathy, an approach they say could address a root driver of nerve pain rather than simply blocking pain signals.

Researchers in Japan have created new vitamin K compounds that are three times more effective than natural forms at turning stem cells into neurons. The work, published in 2025, targets diseases that destroy brain cells such as Alzheimer’s and Parkinson’s.

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Researchers have shown that rejuvenating muscle stem cells from old mice leads to larger muscle growth and improved recovery after injury. The approach could one day help older people regain strength and mobility. Experiments demonstrated clear benefits in leg function and tissue repair.

A widely studied anti-aging treatment triggered significant brain damage in mice, according to new research from the University of Connecticut. The drug combination dasatinib plus quercetin caused myelin loss and changes resembling those seen in multiple sclerosis. The findings raise questions about its use in longevity studies and off-label therapies.

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