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Natural compound may enhance chemotherapy for aggressive leukemia
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Researchers linked to the University of Surrey report that forskolin, a plant-derived compound, can slow the growth of KMT2A‑rearranged acute myeloid leukaemia cells in the lab and increase their sensitivity to the chemotherapy drug daunorubicin. The findings, from a study published in the British Journal of Pharmacology, suggest a possible way to make existing treatments more effective, though further research is required before any change to clinical practice.
Scientists at UBC Okanagan have identified the enzymes plants use to produce mitraphylline, a rare compound with potential anti-cancer properties. This breakthrough solves a long-standing mystery and paves the way for sustainable production of such molecules. The discovery highlights plants' untapped potential in medicine.
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Scientists at RMIT University have created tiny molybdenum oxide nanodots that destroy cancer cells by amplifying their internal stress, while leaving healthy cells largely intact. In lab tests, these particles proved three times more effective against cervical cancer cells than healthy ones. The early-stage research points to a potential for more precise cancer treatments.
Researchers at NYU Langone Health report that inhibiting the protein FSP1 induces ferroptosis and markedly slows lung adenocarcinoma in mouse models. The study, published online in Nature on November 5, 2025, found tumor growth reductions of up to 80% in preclinical tests, according to the institution.
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Researchers in Brazil have identified a molecule in the venom of the Amazonian scorpion Brotheas amazonicus that kills breast cancer cells in vitro with effects similar to the chemotherapy drug paclitaxel, according to FAPESP. Early tests indicate the peptide chiefly induces necrosis, underscoring venoms’ promise as a source of biopharmaceuticals.
Scientists at Texas A&M University Health Science Center have discovered that RNA forms droplet-like hubs in translocation renal cell carcinoma, activating tumor genes. By developing a molecular switch to dissolve these hubs, they halted cancer growth in lab and mouse models. The findings, published in Nature Communications, offer a new approach for treating this aggressive pediatric cancer.
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Researchers at MIT have discovered that the amino acid cysteine can enhance the small intestine's ability to heal itself. In experiments with mice, a cysteine-rich diet activated immune cells to promote tissue regeneration after damage from radiation or chemotherapy. The findings, published in Nature, suggest potential dietary strategies to mitigate treatment side effects.
Spanish researchers develop open-source tool for cancer gene networks
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