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Study suggests the route to whole-genome doubling influences whether DNA-doubled cells survive
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Researchers at Hokkaido University report that cells left with an extra set of DNA after a division error can have markedly different outcomes depending on how the division fails—findings that could help explain why some abnormal cells persist in diseases where whole-genome duplication is common, including cancer.
Cancer cells that reduce MHC class I—a common way to evade CD8+ “killer” T cells—may become more vulnerable to destruction by CD4+ “helper” T cells through ferroptosis, according to research led by Baylor College of Medicine and collaborators at the University of Michigan and published in Nature Immunology.
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New research from Yale shows that oleic acid, the main fat in olive oil, accelerated tumor growth in mice prone to pancreatic cancer, while omega-3 fats from fish oil cut disease development by half.
Researchers at the University of Navarra in Spain have launched RNACOREX, an open-source software that uncovers hidden genetic networks in cancer tumors. The tool analyzes thousands of molecular interactions and predicts patient survival with clarity rivaling advanced AI systems. Tested on data from 13 cancer types, it provides interpretable insights to advance cancer research.
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Researchers linked to the University of Surrey report that forskolin, a plant-derived compound, can slow the growth of KMT2A‑rearranged acute myeloid leukaemia cells in the lab and increase their sensitivity to the chemotherapy drug daunorubicin. The findings, from a study published in the British Journal of Pharmacology, suggest a possible way to make existing treatments more effective, though further research is required before any change to clinical practice.
The Bombay High Court has directed an expert committee to review a plea by Datar Cancer Genetics for approving phase 1 human trials of its cancer immunotherapy drug, Per-C-Vax. The court aims for a report within three months amid disputes over regulatory requirements. The hearing was postponed to March 2, 2026.
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Researchers at Cold Spring Harbor Laboratory have identified key proteins and protein complexes that help certain carcinomas shift their cellular identity and potentially evade treatment. Two new studies, focusing on pancreatic cancer and tuft cell lung cancer, highlight molecular structures that could become targets for more precise and selective therapies.
Protein found to limit CAR T-cell therapy effectiveness
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