Cancer Research
Natural compound may enhance chemotherapy for aggressive leukemia
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Researchers linked to the University of Surrey report that forskolin, a plant-derived compound, can slow the growth of KMT2A‑rearranged acute myeloid leukaemia cells in the lab and increase their sensitivity to the chemotherapy drug daunorubicin. The findings, from a study published in the British Journal of Pharmacology, suggest a possible way to make existing treatments more effective, though further research is required before any change to clinical practice.
Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg have created an AI-powered tool named MAGIC to identify cells with early chromosomal abnormalities linked to cancer. This system automates the detection of micronuclei, small DNA-containing structures that signal potential cancer development. The technology verifies a theory proposed over a century ago by Theodor Boveri.
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Researchers at the University of Waterloo have developed engineered bacteria designed to invade and eat solid tumors from the inside out. The approach uses microbes that thrive in oxygen-free environments, targeting the low-oxygen cores of tumors. A genetic modification allows the bacteria to survive near oxygenated edges, controlled by a quorum-sensing mechanism.
Researchers at Queen Mary University of London have found that rapalink-1, an experimental TOR inhibitor being investigated for cancer therapy, extends the lifespan of fission yeast. The study also uncovered a role for agmatinases in regulating the TOR pathway through a metabolic feedback loop, suggesting potential links between diet, gut microbes, and aging.
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The Bombay High Court has directed an expert committee to review a plea by Datar Cancer Genetics for approving phase 1 human trials of its cancer immunotherapy drug, Per-C-Vax. The court aims for a report within three months amid disputes over regulatory requirements. The hearing was postponed to March 2, 2026.
The Minnesota Wild will host Hockey Fights Cancer Awareness Night on November 16, 2025, during their game against the Vegas Golden Knights. The event, presented by HealthPartners Cancer Care, will feature cancer patients, survivors, and charities, with fans encouraged to wear lavender in support. Various in-game activities and auctions aim to raise funds for cancer research.
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An international team has identified an early 'Big Bang' moment in colorectal (bowel) cancer when tumor cells first evade immune surveillance, a finding that could refine who benefits from immunotherapy. The work, funded by Cancer Research UK and the Wellcome Trust, analyzed samples from 29 patients and was published in Nature Genetics on November 5, 2025.
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