Cancer Research
New biomarker improves early lung cancer detection
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Researchers have identified a novel protein biomarker that detects lung cancer at an early stage with high accuracy. The discovery, detailed in a recent study, could enhance screening methods and improve patient outcomes. Clinical trials showed promising results in identifying the disease before symptoms appear.
Manel Esteller leaves Josep Carreras institute for US role
Spanish researcher Manel Esteller is leaving the Josep Carreras Leukaemia Research Institute in Badalona to lead cancer genomics research at The James Comprehensive Cancer Center of Ohio State University. The move comes amid audits revealing irregularities in fund usage. Esteller expresses enthusiasm for his new chapter in the United States.
New compounds halt cancer growth without damaging healthy cells
Scientists from the Francis Crick Institute and Vividion Therapeutics have developed chemical compounds that prevent the RAS gene from signaling tumor growth via the PI3K pathway. The treatment stopped tumor growth in mice models of lung and breast cancer without causing side effects like hyperglycemia. It is now entering human clinical trials.
Scientists uncover cancer cells' mitochondrial energy surge under pressure
Researchers have discovered that cancer cells respond to physical squeezing by rapidly deploying mitochondria to the nucleus, delivering a burst of ATP to repair DNA damage and ensure survival. This mechanism, observed in lab experiments and patient biopsies, could inspire new strategies to halt cancer spread. The finding redefines mitochondria's role as dynamic responders rather than static energy sources.
Summit's Lung Cancer Drug Shows Promise
Biotech company Summit announced promising results from its lung cancer drug in recent trials. The drug demonstrated potential efficacy in treating advanced cases, marking a step forward in oncology treatments. Further studies are planned to confirm these findings.
Researchers uncover RNA hubs driving kidney cancer growth
Scientists at Texas A&M University Health Science Center have discovered that RNA forms droplet-like hubs in translocation renal cell carcinoma, activating tumor genes. By developing a molecular switch to dissolve these hubs, they halted cancer growth in lab and mouse models. The findings, published in Nature Communications, offer a new approach for treating this aggressive pediatric cancer.